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Yuemao Shen Selected Research

geldanamycin

5/2023LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model.
12/2019Synthesis and biological evaluation of geldanamycin-ferulic acid conjugate as a potent Hsp90 inhibitor.
6/201517-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation.
2/2015Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.
1/2015The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells.
10/2014Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.

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Yuemao Shen Research Topics

Disease

20Neoplasms (Cancer)
12/2023 - 09/2008
3Inflammation (Inflammations)
12/2023 - 11/2003
3Lung Neoplasms (Lung Cancer)
12/2023 - 04/2007
3Prostatic Neoplasms (Prostate Cancer)
08/2015 - 01/2015
2Neoplasm Metastasis (Metastasis)
12/2023 - 02/2023
2Carcinogenesis
02/2023 - 11/2020
2Uterine Cervical Neoplasms (Cancer of the Cervix)
05/2017 - 01/2014
2Breast Neoplasms (Breast Cancer)
11/2014 - 01/2014
1Triple Negative Breast Neoplasms
12/2023
1Drug-Related Side Effects and Adverse Reactions
01/2021
1Dehydration (Water Stress)
01/2021
1COVID-19
01/2021
1Cytokine Release Syndrome
01/2021
1Testicular Neoplasms (Testicular Cancer)
01/2021
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2021
1Autoimmune Diseases (Autoimmune Disease)
01/2019
1Colorectal Neoplasms (Colorectal Cancer)
01/2018
1Atherosclerosis
01/2015
1Cholangiocarcinoma
06/2014
1Pathologic Processes
11/2013
1Osteoporosis
01/2013
1Ataxia Telangiectasia (Louis Bar Syndrome)
10/2012
1Insulin Resistance
08/2012
1Type 2 Diabetes Mellitus (MODY)
08/2012
1Septic Shock (Toxic Shock Syndrome)
01/2012
1Bacterial Infections (Bacterial Infection)
12/2011
1Hypoglycemia (Reactive Hypoglycemia)
09/2008

Drug/Important Bio-Agent (IBA)

6geldanamycinIBA
05/2023 - 10/2014
4Proteins (Proteins, Gene)FDA Link
02/2023 - 06/2015
3Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2023 - 02/2023
3Etoposide (VP 16)FDA LinkGeneric
12/2022 - 12/2019
2Oncogene Proteins (Oncogene Protein)IBA
02/2023 - 04/2007
2Teniposide (VM 26)FDA Link
01/2021 - 01/2020
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
04/2016 - 01/2016
2Phosphotransferases (Kinase)IBA
04/2016 - 10/2012
2AndrogensIBA
08/2015 - 01/2015
2Heat-Shock Proteins (Heat-Shock Protein)IBA
08/2015 - 06/2015
2mycoepoxydieneIBA
01/2015 - 06/2014
1ResveratrolIBA
12/2023
1lapacholIBA
12/2023
1Type II DNA Topoisomerases (Topoisomerase II)IBA
12/2022
14'-demethylepipodophyllotoxinIBA
08/2021
1TriazolesIBA
08/2021
1ThiadiazolesIBA
08/2021
1Podophyllotoxin (Condylox)FDA LinkGeneric
01/2021
1polyporic acidIBA
01/2021
1verucopeptinIBA
11/2020
1Mechanistic Target of Rapamycin Complex 1IBA
11/2020
1Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA
11/2020
1Adenosine Triphosphatases (ATPase)IBA
11/2020
1Topoisomerase InhibitorsIBA
12/2019
1ferulic acid (sodium ferulate)IBA
12/2019
1Tyrosine (L-Tyrosine)FDA Link
01/2019
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2019
1Protein Tyrosine PhosphatasesIBA
01/2019
1TubulinIBA
01/2018
1EnzymesIBA
05/2017
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016
1LigandsIBA
01/2016
1Cadherins (E-Cadherin)IBA
06/2015
1Androgen Receptors (Androgen Receptor)IBA
06/2015
117- (6- (3,4- dimethoxycinnamamido)hexylamino)- 17- demethoxy- geldanamycinIBA
06/2015
1SurvivinIBA
06/2015
1Molecular Chaperones (Chaperone, Molecular)IBA
06/2015
1Transcription Factors (Transcription Factor)IBA
06/2015
1VimentinIBA
06/2015
1oxidized low density lipoproteinIBA
01/2015
1Apolipoproteins E (ApoE)IBA
01/2015
1tanespimycin (17AAG)IBA
11/2014
1trioctyl phosphine oxide (TOPO)IBA
10/2014
1lissamine rhodamine B (sulforhodamine B)IBA
01/2014
1Histone Deacetylase InhibitorsIBA
11/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2012
1Insulin (Novolin)FDA Link
08/2012
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
08/2012
1Blood Glucose (Blood Sugar)IBA
08/2012
1Glucose (Dextrose)FDA LinkGeneric
08/2012
1CytokinesIBA
01/2012
1Biological Control AgentsIBA
12/2011
1deacety mycoepoxydieneIBA
04/2011
1Cytochromes c (Cytochrome c)IBA
09/2008
1Indicators and Reagents (Reagents)IBA
09/2008
1cytosporone BIBA
09/2008
1Doxorubicin (Adriamycin)FDA LinkGeneric
04/2007
1AlkaloidsIBA
11/2003

Therapy/Procedure

6Therapeutics
01/2021 - 01/2015
3Drug Therapy (Chemotherapy)
01/2021 - 12/2019
1Castration
01/2015
1Ovariectomy (Oophorectomy)
01/2013